92194-60-0Relevant academic research and scientific papers
Solvent-free reaction between anthranilic acids and isocyanides: A novel approach for the synthesis of 2-unsubstituted 4(3 H)-quinazolinones
Adib, Mehdi,Karimzadeh, Morteza,Mahdavi, Mohammad,Sheikhi, Ehsan,Mirzaei, Peiman
, p. 834 - 836 (2011)
A novel synthesis of 2-unsubstituted 4(3H)-quinazolinones is described. Heating a mixture of an anthranilic acid and an isocyanide under solvent-free conditions afforded the title compounds in good to excellent yields. Georg Thieme Verlag Stuttgart.
Base-promoted ring opening of 3-chlorooxindoles for the construction of 2-aminoarylthioates and their transformation to quinazolin-4(3: H)-ones
Poudel, Tej Narayan,Khanal, Hari Datta,Lee, Yong Rok
supporting information, p. 4735 - 4741 (2018/03/21)
An unprecedented methodology for the preparation of diverse S-alkyl 2-aminoarylthioates has been developed based on cesium carbonate-promoted direct ring opening of 3-chlorooxindoles with thiols. This novel protocol proceeds via cascade sulfenylation, aer
Discovery of molluscicidal and cercaricidal activities of 3-substituted quinazolinone derivatives by a scaffold hopping approach using a pseudo-ring based on the intramolecular hydrogen bond formation
Guo, Wei,Zheng, Lv-Yin,Li, Yong-Dong,Wu, Ren-Miao,Chen, Qiang,Yang, Ding-Qiao,Fan, Xiao-Lin
supporting information, p. 291 - 294 (2016/04/05)
Discovery of novel topological agents against Oncomelania hupensis snails and cercariae remains a significant challenge in current Schistosomiasis control. A pseudo-ring formed from salicylanilide by an intramolecular hydrogen bond led to the discovery of 3-substituted quinazolinone derivatives which showed a potent molluscicidal and cercaricidal activities.
4-Quinazolinones: Synthesis and reduction of prostaglandin E2 production
Santagati, Natale Alfredo,Bousquet, Ennio,Spadaro, Angelo,Ronsisvalle, Giuseppe
, p. 780 - 784 (2007/10/03)
We synthesized and evaluated the anti-inflammatory activity of a series of 4-quinazolinone derivatives. Two approaches were used to yield the title compounds. A first group of quinazolinone derivatives was obtained by the appropriate substituted anthranilates. A second group of quinazolinone compounds was prepared through the benzoxazin-4-ones intermediate. The pharmacological results reveal that the synthesized derivatives exhibit a significant anti-inflammatory effect in an experimental ocular inflammation model. In fact, all the tested compounds lowered the prostaglandin E2 (PGE2) production with respect to the control group (P 2 levels even more than the reference drug tolmetin and significantly lower protein concentration and polymorphonuclear leukocytes number compared to the control group (P 0.05). Therefore, these compounds may be useful to prevent ocular inflammatory reactions.
