92234-45-2Relevant academic research and scientific papers
Synthesis of optically active 4,5-dihydroisoxazolecarboxylic acids
Zadrozna, Irmina,Kurkowska, Joanna,Makuch, Iwona
, p. 111 - 118 (2007/10/03)
A series of regioisomers of 4,5-dihydroisoxazolecarboxylates have been synthesized in the 1,3-dipolar intermolecular cycloaddition and subjected to enzymatic hydrolysis by α-chymotrypsin from bovine pancreas (type II) and to microbial hydrolysis by an Aspergillus niger fungus. For some compounds this hydrolysis time led to the obtaining of a racemic mixture, and for others the reaction was enantioselective.
4,5-Dihydroisoxazoles. Regioselectivity in the 1,3-Dipolar Cycloaddition of Nitrile Aliphatic Oxides to Cinnamic Acid esters. NMR Criteria
Zadrozna, Irmina,Kornacka, Elzbieta
, p. 363 - 372 (2007/10/03)
A systematic study of the electron and steric effects on the ratio of regioisomers of 4,5-dihydroisoxazoles has been carried out.The compounds have been prepared from aliphatic nitril oxides and methyl esters of p-substituted cinnamic acid or phenyl cinnamate.The regioisomers of substituted 4,5-dihydroisoxazoles have been established based on 1H NMR and 13C NMR spectra.
