92245-81-3Relevant academic research and scientific papers
Mild reductive functionalization of amides into N-sulfonylformamidines
Trillo, Paz,Slagbrand, Tove,Tinnis, Fredrik,Adolfsson, Hans
, p. 484 - 487 (2017)
The development of a protocol for the reductive functionalization of amides into N-sulfonylformamidines is reported. The one-pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)6 (molybdenum hexacarbonyl) and TMDS (1,1,3,3-tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.
Preparation method and application of N-benzenesulfonyl formamidine compound
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Paragraph 0048; 0049-0051; 0073-0075, (2022/04/03)
The invention relates to a preparation method and application of an N-benzenesulfonyl formamidine compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: adding secondary amine, cyano sulfonyl oxime ether, organic alkali and a solvent into a reactor, carrying out a stirring reaction at a certain temperature for a period of time, and after the reaction is completed, carrying out washing, extraction, drying, separation, rotary evaporation and purification to obtain a target product N-benzenesulfonyl formamidine compound. The preparation method of the N-benzenesulfonyl formamidine compound can be applied to structural later-stage modification of drug molecules and drug intermediates, and the obtained compound has potential application in the aspect of sterilization. The synthetic reaction route has the characteristics of simplicity and convenience in operation, mild conditions, high yield, relatively easiness in post-treatment, suitability for large-scale preparation and the like.
Unexpected C=N bond formation via NaI-catalyzed oxidative de-tetra-hydrogenative cross-couplings between N,N-dimethyl aniline and sulfamides
Zheng, Yang,Mao, Jincheng,Chen, Jie,Rong, Guangwei,Liu, Defu,Yan, Hong,Chi, Yongjian,Xu, Xinfang
, p. 50113 - 50117 (2015/06/25)
A direct and convenient C=N bond formation reaction was reported, which was a de-tetra-hydrogenative cross-coupling (DTCC) reaction between N,N-dimethyl aniline and sulfamide under transition-metal-free conditions, and to give sulfonyl amidine derivatives in moderate to high yields.
