922500-91-2

Basic information

• Product Name: ethyl 2-(oxetan-3-ylidene)acetate
• Synonyms: Acetic acid, 2-(3-oxetanylidene)-, ethyl ester;ethyl 2-(oxetan-3-ylidene)acetate;Ethyl 2-(oxetan-3-ylidene...;Ethyl oxetan-3-ylideneacetate;oxetan-3-ylidene-acetic acid ethyl ester
• CAS NO: 922500-91-2
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142
• Mol File: 922500-91-2.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 207℃
• Flash Point: 78℃
• Appearance: /
• Density: 1.228
• Vapor Pressure: 0.229mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: ethyl 2-(oxetan-3-ylidene)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(oxetan-3-ylidene)acetate(922500-91-2)
• EPA Substance Registry System: ethyl 2-(oxetan-3-ylidene)acetate(922500-91-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 922500-91-2(Hazardous Substances Data)

Usage

Uses

Ethyl 2-(Oxetan-3-ylidene)acetate is a CBL-?B inhibitors which is used in the treatment of cancer.

InChI:InChI=1/C7H10O3/c1-2-10-7(8)3-6-4-9-5-6/h3H,2,4-5H2,1H3

Upstream product

• 6704-31-0 oxetan-3-one 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 126822-95-5 oxetone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 922501-10-8 [3-(4-tert-butyl-benzyl)-oxetan-3-yl]-acetic acid ethyl ester 
• 1050611-00-1 ethyl 2-(3-cyanooxetan-3-yl)acetate 
• 1453862-19-5 ethyl 2-(3-(3-fluoro-4-hydroxyphenyl)oxetan-3-yl)acetate 
• 1453861-77-2 ethyl 2-(3-(4-((4'-(methylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-78-3 2-(3-(4-((4'-(methylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-79-4 ethyl 2-(3-(4-((4'-(butylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-80-7 2-(3-(4-((4'-(butylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-81-8 ethyl 2-(3-(4-((4'-(3-(methylsulfonyl)propoxy)-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-82-9 2-(3-(4-((4'-(3-(methylsulfonyl)propoxy)-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-83-0 ethyl 2-(3-(4-((4'-(isopropylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-84-1 2-(3-(4-((4'-(isopropylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-92-1 ethyl 2-(3-(3-fluoro-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-93-2 2-(3-(3-fluoro-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-94-3 ethyl 2-(3-(4-((4-fluoro-3-(trifluoromethoxy)benzyl)oxy)phenyl)oxetan-3-yl)acetate 

Relevant articles and documents

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The preparation method comprises the following steps: taking 3-oxetanone (compound II) as an initial raw material, and carrying out Wittig reaction on the initial raw material and triethyl phosphonotriacetate under an alkaline condition to obtain a compound III; carrying out coupling reaction on the compound III and a boric acid compound IV to obtain a compound V; reducing the ester group of the compound V to generate a compound VI; carrying out nucleophilic substitution reaction on hydroxyl of the compound VI and sulfonyl chloride/sulfonic anhydride to generate a compound VII; reacting hydroxyl of the compound VI with a halogenating reagent to generate a compound VIII; carrying out elimination reaction on the compound VII or the compound VIII to generate a compound IX; and finally, oxidizing the double bonds of the compound IX to generate 3-(substituted phenyl) oxetane-3-carboxylic acid (compound I). The method is easy and convenient to operate and high in yield, the total yield can reach 35%, and large-scale production can be achieved.

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