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922508-26-7

2'-TBDMS-5-Me-rU is a modified nucleoside that is a derivative of uridine, a nucleoside found in RNA. It features a tert-butyldimethylsilyl (TBDMS) protective group at the 2' position of the ribose sugar and a methyl group at the 5' position of the uracil base. These modifications are utilized in nucleoside chemistry to safeguard and regulate the reactivity of the nucleosides during synthesis processes.
Used in Nucleic Acid Research:
2'-TBDMS-5-Me-rU is used as a research compound for the development of RNA-based therapeutics and diagnostics. Its protective groups and modifications allow for controlled synthesis and manipulation of nucleosides, which is crucial for creating novel RNA molecules with potential applications in medicine and biotechnology.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-TBDMS-5-Me-rU is used as a building block for the synthesis of complex RNA molecules. Its protective groups facilitate the creation of stable and specific RNA structures that can be employed as therapeutic agents or for targeted drug delivery.
Used in Diagnostics:
2'-TBDMS-5-Me-rU is used as a component in the development of diagnostic tools that rely on RNA interactions. Its unique structure can be tailored to bind with specific RNA sequences, enabling the detection and analysis of various genetic markers and diseases.
Used in Chemical Synthesis:
2'-TBDMS-5-Me-rU is used as a synthetic intermediate in the preparation of other nucleoside derivatives. Its protective groups make it easier to perform selective reactions, which is essential for creating a wide range of nucleoside analogs with diverse applications in research and medicine.

922508-26-7

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922508-26-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 922508-26-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,2,5,0 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 922508-26:
(8*9)+(7*2)+(6*2)+(5*5)+(4*0)+(3*8)+(2*2)+(1*6)=157
157 % 10 = 7
So 922508-26-7 is a valid CAS Registry Number.

922508-26-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names Uridine,2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:922508-26-7 SDS

922508-26-7Downstream Products

922508-26-7Relevant articles and documents

Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase

Allan, Amy L.,Gladstone, Patricia L.,Price, Melissa L. P.,Hopkins, Stephanie A.,Juarez, Jose C.,Do?ate, Fernando,Ternansky, Robert J.,Shaw, David E.,Ganem, Bruce,Li, Yingbo,Wang, Weiru,Ealick, Steven

, p. 7807 - 7815 (2006)

A series of novel, multisubstrate, bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (TP) is described. Thymidine phosphorylase has been implicated in angiogenesis and plays a significant role in tumor progression and metastasis.

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