92252-23-8Relevant academic research and scientific papers
Efficient preparation method of 4-hydroxybenzoic esters – Oxidation of substituted Hagemman's ester
Kang, Sein,Kim, Dahye,In, Ik Joon,Koo, Sangho
, p. 2264 - 2266 (2018/03/26)
A practical two-step synthetic method of diversely R-substituted 4-hydroxybenzoic esters, which may have wide applications in household chemicals and polymeric materials, was developed by 2:1 coupling between ethyl acetoacetate and aldehydes (RCHO) in t-BuOK/t-BuOH, followed by oxidative aromatization of the resulting Hagemman's esters. Application of the condition using stoichiometric NBS and catalytic TMS·OTf efficiently induced oxidation of the Hagemman's esters to produce 4-hydroxybenzoic esters.
High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations
Ramachary, Dhevalapally B.,Narayana, Vidadala V.,Prasad, M. Shiva,Ramakumar, Kinthada
body text, p. 3372 - 3378 (2010/01/06)
An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.
Organocatalytic cascade reactions based on push-pull dienamine platform: Synthesis of highly substituted anilines
Ramachary, Dhevalapally B.,Ramakumar, Kinthada,Narayana, Vidadala V.
, p. 1458 - 1463 (2007/10/03)
(Chemical Equation Presented) A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiary lamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.
Synthesis of substituted cyclohex-2-enones
Ahmed,Ahmed,Romman,Akhter,Chowdhury,Kiuchi
, p. 710 - 712 (2007/10/03)
Ethyl acetoacetate reacts with benzylideneacetone, 2-methoxy benzylideneacetone and furfurylideneacetone in the presence of sodium ethoxide as catalyst to yield 4-ethoxycarbonyl-3-methyl-5-phenylcyclohex-2-enone 1a, 4-ethoxycarbonyl-3-methyl-5-(2-methoxyphenyl) cyclohex-2-enone 1b and 4-ethoxycarbonyl-5-(2-furanyl)-3-methylcyclohex-2-enone 1c, respectively. Ethyl benzoylacetate reacts with benzylideneacetone and furfurylideneacetone in the presence of sodium ethoxide to give 4-ethoxycarbonyl-3,5-bis-phcnylcyclohex-2-enone 1d and 4-ethoxycarbonyl-5-(2-furanyl)-3-phenylcyclohex-2-enone 1e, respectively as products.
ARYLAMINATION OF 2,4-DIACETYL(DIETHOXYCARBONYL)-5-HYDROXY-5-METHYL-3-PHENYL(2-FURYL)-1-CYCLOHEXANONES
Sorokin, V. V.,Kuz'min, M. V.,Smirnova, N. S.,Kozhevnikova, N. I.,Kriven'ko, A. P.
, p. 562 - 565 (2007/10/02)
The arylamination of 2,4-diacetyl(diethoxycarbonyl)-5-hydroxy-5-methyl-3-phenyl(2-furyl)-1-cyclohexanones takes place with participation of the carbonyl group of the alicycle and retention or elimination of the hydroxyl function and leads to the formation
