92265-01-5 Usage
Uses
Used in Biochemistry Research:
BOC-TYR(PO3BZL2)-OH is used as a research tool for understanding the role of phosphorylated tyrosine residues in biological systems. Its presence allows for the investigation of protein kinase activities and the impact of tyrosine phosphorylation on cellular signaling.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, BOC-TYR(PO3BZL2)-OH is utilized for the development of drugs targeting protein kinases, which are enzymes that add phosphate groups to proteins. BOC-TYR(PO3BZL2)-OH can be used to design inhibitors or activators of these enzymes, potentially leading to treatments for diseases associated with abnormal kinase activity.
Used in Peptide Synthesis:
BOC-TYR(PO3BZL2)-OH is used as a building block in the synthesis of phosphopeptides, which are short chains of amino acids that include phosphorylated residues. These phosphopeptides are important for studying the effects of phosphorylation on protein function and for developing peptide-based drugs.
Used in Drug Development:
BOC-TYR(PO3BZL2)-OH is employed in the development of drugs that modulate the activity of proteins involved in cell signaling. By incorporating BOC-TYR(PO3BZL2)-OH into drug molecules, researchers can potentially create therapies that influence the phosphorylation state of target proteins, impacting a range of diseases related to cellular signaling dysregulation.
Used in Analytical Chemistry:
BOC-TYR(PO3BZL2)-OH can also be used in analytical chemistry for the development of assays and sensors that detect and measure the activity of protein kinases or the presence of phosphopeptides, providing valuable tools for diagnostic and research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 92265-01-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,2,6 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 92265-01:
(7*9)+(6*2)+(5*2)+(4*6)+(3*5)+(2*0)+(1*1)=125
125 % 10 = 5
So 92265-01-5 is a valid CAS Registry Number.
92265-01-5Relevant academic research and scientific papers
An Improved One-pot Synthesis of Nα-(tert-Butoxycarbonyl)-O-(O',O"-dialkylphosphoro)-L-tyrosines Using Dialkyl N,N-Diethylphosphoramidites
Perich, John W.,Johns, R. B.
, p. 701 - 703 (2007/10/02)
Nα-(tert-Butoxycarbonyl)-O-(O',O"-dialkylphosphoro)-L-tyrosines 6a-c were prepared in high yields by an efficient one-pot procedure, which involved initial tert-butyldimethylsilyl protection of the carboxy terminus of N-Boc tyrosine 1 followed
Liquid Secondary Ionization Mass Spectrometric Characterization of Two Synthetic Phosphotyrosine-Containing Peptides
Gibson, Bradford W.,Falick, Arnold M.,Burlingame, A. L.,Nadasdi, Lazslo,Nguyen, Ann Cac,Kenyon, George L.
, p. 5343 - 5347 (2007/10/02)
N-(tert-Butoxycarbonyl)-Q-(dibenzylphosphono)-L-tyrosine (1), a suitably protected phosphotyrosine, has been prepared for peptide synthesis.Compound 1 and its intermediate precursors were characterized by elemental analyses, liquid secondary ion mass spec
SYNTHESIS OF PROTECTED DERIVATIVES OF O-PHOSPHOTYROSINE INCORPORATION IN A HEPTAPEPTIDE
Valerio, R. M.,Alewood, P. F.,Johns, R. B.,Kemp, B. E.
, p. 2609 - 2612 (2007/10/02)
The solid phase synthesis of the phosphopeptide Leu-Arg-Ala-Tyr(P)-Leu-Gly is reported via stepwise incorporation of the protected phosphoamino acid Nα-tert-butyloxycarbonyl-O-dimethyl-phosphono-L-tyrosine.
