92279-07-7Relevant academic research and scientific papers
Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells
Kubo, Isao,Nihei, Ken-Ichi,Tsujimoto, Kazuo
, p. 5349 - 5354 (2007/10/03)
p-Coumaric acid and methyl p-coumarate inhibit the oxidation of l-tyrosine catalyzed by mushroom tyrosinase. However, both were oxidized as monophenol substrate analogues at an extremely slow rate. Methyl p-coumarate significantly suppressed the melanin formation in B16 mouse melanoma cells, whereas p-coumaric acid did not show this activity. p-Coumaric acid (4-hydroxycinnamic acid) and methyl p-coumarate (methyl 4-hydroxycinnamate) inhibit the oxidation of l-tyrosine catalyzed by mushroom tyrosinase. However, both were oxidized as monophenol substrate analogues at an extremely slow rate. This oxidation was significantly accelerated as soon as catalytic amounts (0.01 mM) of l-3,4-dihydroxyphenylalanine (l-DOPA) became available as a co-factor. Methyl p-coumarate significantly suppressed the melanin formation in B16 mouse melanoma cells, whereas p-coumaric acid did not show this activity.
TRAPPING OF DOPACHROME WITH 2,3-DIHYDRO-1H-CYCLOPENTINDOLE
Omote, Yoshimori,Tomotake, Atsushi,Kashima, Choji
, p. 2993 - 2994 (2007/10/02)
Dopachrome (6) and related o-benzoquinones including dopaquinone (2d) were trapped, by treating each quinone from the corresponding catechol, with 2,3-dihydro-1H-cyclopent-indole (3) to afford -propellane adduct.
