923-37-5

Usage

Uses

Used in Proteomics Research:
CARBAMOYL-DL-ASPARTIC ACID is used as a biochemical for proteomics research, aiding in the study and analysis of proteins and their functions within biological systems.
Used in Pyrimidine Biosynthesis:
In the field of biochemistry, CARBAMOYL-DL-ASPARTIC ACID is utilized as an intermediate in the biosynthesis of pyrimidine, which is an essential component of nucleic acids and plays a crucial role in various cellular processes.

InChI:InChI=1/C5H8N2O5/c6-5(12)7-2(4(10)11)1-3(8)9/h2H,1H2,(H,8,9)(H,10,11)(H3,6,7,12)/p-2/t2-/m0/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 57-13-6 urea 
• 110-16-7 maleic acid 
• 617-45-8 aspartic Acid 
• 155-54-4 4,5-dihydroorotic acid 
• 590-28-3 potassium cyanate 

Downstream Products

• 65-86-1 orotic acid 
• 5427-26-9 5-hydantoinacetic acid 

Relevant academic research and scientific papers

Flame-induced addition of urea to unsaturated carboxylic acids

When a hydrogen-oxygen flame was blown against an aqueous solution of urea and maleic acid, N-carbamoylaspartic acid was generated. This compound seemed to be formed by the addition of an amidinoxyl radical to a C-C double bond of the acid, followed by a thermal rearrangement of an amidinoxy to a ureido group.

Formation of N-Carbamoylaspartic Acid and Its Cyclisation to Orotic Acid

The stereochemistries of the reactions between cyanate and aspartic acid and 3-methylaspartic acid have been examined.The product of the first reaction, N-carbamoylaspartic acid 3, can cyclise to give either dihydroorotic acid 5 or 5-carboxymethylmydantoin 4.Acid catalysed cyclisation gives the latter while catalysis by the enzyme dihydroorotase gives the former.Introduction of a double bond into 3 changes the course of non-enzymatic cyclisation and a six-membered ring compound orotic acid 1 is the product.It is proposed that the double bond prevents intramolecular hydrogen bonding.

β-UREIDO ACIDS AND DIHYDROURACILS. PART 15. EFFECT OF ALLYLIC STRAIN ON RING OPENING OF 1,6-DISUBSTITUTED DIHYDROURACILS

The rate profiles for the alkaline hydrolysis of some dihydrouracil and dihydro-orotic acid derivetives have been measured in order to assess the effect of allylic strain on the ring opening of 1,6-disubstituted dihydrouracils.The introduction of a 1-nitrogen-substituent in the 6-substituted compounds brings about a substantial decrease (40-500 times) in the observed rate constant which is second order in hydroxide ion (k1k3/k-1).The rate decreases of the addition step, k1, are moderate and in the range expected from the observed shifts in conformational equilibra towards the axial conformation which gives rise to a hindered transition state.The major contribution to the rate decreases from the ring-opening step, k3/k-1, and have been attributed to strains of the type associated with gem-dimethyl effect upon ring closure.