923010-55-3Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
Kamata, Makoto,Yamashita, Tohru,Kina, Asato,Funata, Masaaki,Mizukami, Atsushi,Sasaki, Masako,Tani, Akiyoshi,Funami, Miyuki,Amano, Nobuyuki,Fukatsu, Kohji
, p. 3643 - 3647 (2012/07/17)
Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the
