923010-92-8

Basic information

• Product Name: benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate
• CAS NO: 923010-92-8
• Molecular Weight: 400.518
• Mol File: 923010-92-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate(923010-92-8)
• EPA Substance Registry System: benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate(923010-92-8)

Safety Data

• Hazardous Substances Data: 923010-92-8(Hazardous Substances Data)

Upstream product

• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 1263283-85-7 C₁₀H₁₇NO₂ 
• 923009-67-0 tert-butyl 3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]decane-7-carboxylate 
• 923009-61-4 C₁₆H₂₇NO₅ 
• 923009-60-3 1-tert-butyl 3-ethyl 3-(2-methylprop-2-en-1-yl)piperidine-1,3-dicarboxylate 

Downstream Products

• 1345817-62-0 (5R)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate 
• 1345817-61-9 (5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors

The co-crystal structure of the human acetyl-coenzyme A 2 (ACC2) carboxyl transferase domain and the reported compound CP-640186 (1b) suggested that two carbonyl groups are essential for potent ACC2 inhibition. By focusing on enhancing the interactions between the two carbonyl groups and the amino acid residues Gly2162 and Glu2230, we used ligand- and structure-based drug design to discover spirolactones bearing a 2-ureidobenzothiophene moiety