923037-67-6

Basic information

• Product Name: Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel-
• CAS NO: 923037-67-6
• Molecular Formula: C22H27NO4S
• Molecular Weight: 401.527
• Mol File: 923037-67-6.mol

Chemical Properties

• CAS DataBase Reference: Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel-(923037-67-6)
• EPA Substance Registry System: Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel-(923037-67-6)

Safety Data

• Hazardous Substances Data: 923037-67-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-relis used as an intermediate in the synthesis of rac,trans-Milnacipran Hydrochloride (M344625), which is an impurity of rac-Milnacipran Hydrochloride (M344600). Rac-Milnacipran Hydrochloride is an antidepressant medication and a selective norepinephrine and serotonin reuptake inhibitor, used for the treatment of major depressive disorder and fibromyalgia. The synthesis of Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel- helps in the production of a more effective and safer antidepressant drug.

Upstream product

• 63106-93-4 (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 172015-99-5 (1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 131091-01-5 (1R,2R)-2-Hydroxymethyl-1-phenyl-cyclopropanecarboxylic acid diethylamide 

Relevant articles and documents

Preparation of leveminacipran hydrochloride

The invention discloses a novel preparation method for synthesizing leveminacipran hydrochloride, and relates to a compound represented by a formula A. According to the invention, each step of reaction is simple in operation and mild in condition, use of

1-Aryl-2-(aminomethyl)cyclopropanecarboxylic Acid Derivatives. A New Series of Potential Antidepressants

A series of 1-aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives were synthesized and evaluated as potential antidepressants.Compounds with the Z configuration were synthesized from 1-aryl-2-oxo-3-oxabicyclohexane and those with E configuration from (E)-1-phenyl-2-(hydroxymethyl)cyclopropanecarboxylic acid.The compounds were evaluated in animal tests designed to reveal potential antidepressant activity and the existence of undesirable side effects.Several derivatives were more active than imipramine and desipramine.On the basis of its activity in pharmacological animal tests of antidepressant activity and its potential lack of side effects, 1-phenyl-1--2-(aminomethyl)cyclopropane hydrochloride, midalcipran (INN), was selected for further development.This compound is currently in phase III clinical evaluation.