92328-97-7

Upstream product

• 386218-05-9 2-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione 
• 38212-33-8 4-(4-chlorophenyl) piperazine 

Downstream Products

• 1360625-54-2 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-4-isoquinolinesulfonamide hydrochloride 
• 1364122-05-3 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-4-isoquinolinesulfonamide 
• 1360625-51-9 N-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}-4-quinolinesulfonamide hydrochloride 
• 1360684-71-4 N-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}-4-quinolinesulfonamide 
• 1360625-52-0 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-6-quinoline sulfonamide hydrochloride 
• 1360684-72-5 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-6-quinoline sulfonamide 
• 1360625-53-1 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-7-quinoline sulfonamide hydrochloride 
• 1360684-73-6 N-{4-[4-(4-chlorophenyl)piperazin-1-yl]butyl}-7-quinoline sulfonamide 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a identified a series of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide D3 ligands. Members of this class are highly selective for D3 versus D2, and we have identified two compounds (13g and 13r) whose rat in vivo IV pharmacokinetic properties that indicate that they are suitable for assessment in in vivo efficacy models of substance use disorders.

Design, synthesis and evaluation of bitopic arylpiperazinephenyl-1,2,4-oxadiazoles as preferential dopamine D3 receptor ligands

The dopamine D3 receptor (D3R) was proposed as a therapeutic target for drug development to treat drug abuse and addiction and neuropsychiatric disorders. Several D3R-selective modulators over the dopamine D2 receptor (D2R) can avoid extrapyramidal sympto

An interactive SAR approach to discover novel hybrid thieno probes as ligands for D2-like receptors with affinities in the subnanomolar range

A series of [(phenylpiperazinyl)alkyl]-isoindole-1,3-dione derivatives was synthesized to serve as probes for dopaminergic receptors. Among this series, compound 6a showed the highest affinity towards D4 and D3 receptors with K i values in the low nanomolar range, and D2/D4- and D2/D3-selectivity indices of 72 and 20, respectively. Optimization rounds were adopted and led to the D4-selective ligand thiophene-2-carboxamide 9a with a Ki(D4) value of 0.62 nM, and to its butyl analog, 10a, with Ki(D4) and Ki(D3) values of 0.03 and 0.26 nM, respectively. Docking experiments revealed the importance of the unique D4 residue Arg186 in manipulating the ligands' D4-subtype-receptor selectivity. Copyright