923291-09-2

Upstream product

• 1447969-80-3 N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine 
• 148692-01-7 N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine 
• 1447969-81-4 N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine 

Downstream Products

• 923291-10-5 N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine 
• 923291-12-7 N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine-3’-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 

Relevant academic research and scientific papers

2′-O-{[2,2-dimethyl-2-(2-nitrophenyl) acetyl] oxy} methyl protecting group for RNA synthesis

A new 2′-OH protecting group, {[2,2-dimethyl-2-(2-nitrophenyl)acetyl] oxy} methyl (DAM), has been successfully applied to RNA oligonucleotides synthesis with high coupling efficiency. The 2′-O-DAM method is fully compatible with reagents and conditions employed in automated solid phase synthesis of RNA. Moreover, it can be easily removed via reduction in near-neutral solution.