92356-67-7

Upstream product

• 67629-62-3 methyl 4-(diethylphosphono)crotonate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 623-43-8 crotonic acid methyl ester 

Downstream Products

• 28169-16-6 5-(3,4-dimethoxyphenyl)penta-(2E,4E)-dienoic acid 
• 152867-91-9 (E,E)-5-(3',4'-Dimethoxyphenyl)penta-2,4-dienoyl-chlorid 
• 66110-19-8 (2E,4E)-5-(3,4-dimethoxyphenyl)-1-(piperidin-1-yl)penta-2,4-diene-1-one 

Relevant academic research and scientific papers

An effective strategy to develop active cinnamic acid-directed antioxidants based on elongating the conjugated chains

To optimize antioxidant activity and lipophilicity of cinnamic acid derivatives (CAs) including ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, and p-hydroxycinnamic acid, four analogs bearing an additional double bond between their aromatic ring and propenoic acid moiety were designed and synthesized based on the conjugated chain elongation strategy. The antioxidant performance of the CAs were investigated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH)-scavenging, ferric reducing/antioxidant power, cyclic voltammetry, DNA strand breakage-inhibiting and anti-haemolysis activity assays. It was found that CAs with elongation of conjugated chains display increased DPPH --scavenging, DNA strand breakage-inhibiting and anti-haemolysis activities as compared to their parent molecules, due to their improved hydrogen atom-donating ability and lipophilicity. Overall, this work highlights an effective strategy to develop potential CA-directed antioxidants by elongating their conjugated chain.

Synthetic and spectroscopic studies of structural analogs of piper amides - The 5-aryl-2E,4E-pentadienamides

The methyl esters and piperidides of fourteen 5-aryl-2E,4E-pentadienoic acids have been synthesized starting from the corresponding aryl aldehydes.

Substituent Effects on Carbon-13 NMR Chemical Shifts of Side-chain Carbons in 5-Aryl-2E,4E-pentadienoic Acid Derivatives

The 13C NMR spectra of two series of 5-aryl-2E,4E-pentadienoic acid derivatives, viz. the methyl esters and piperidides have been determined.The chemical shifts of C-2 and C-4 show very good correlations with the Hammett ?+-constants for all the substituents investigated, except for the para-nitro group which is capable of excerting a strong -R effect.A possible explanation for this has been advanced.Hammett correlations between substituents and the chemical shifts of both C-3 and C-5 carbons using ?0 parameters are less satisfactory.A reverse chemical shift effect has been observed for these two centres.