923570-07-4

Basic information

• Product Name: [(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid tert-butyl ester
• Synonyms: [(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid tert-butyl ester
• CAS NO: 923570-07-4
• Molecular Weight: 376.453
• Mol File: 923570-07-4.mol

Chemical Properties

• CAS DataBase Reference: [(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid tert-butyl ester(923570-07-4)
• EPA Substance Registry System: [(S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid tert-butyl ester(923570-07-4)

Safety Data

• Hazardous Substances Data: 923570-07-4(Hazardous Substances Data)

Upstream product

• 2448-45-5 Cbz-D-Phe 

Downstream Products

• 918902-32-6 2-chloro-{(3R)-1-[(2S)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide 

Relevant articles and documents

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors

A series of substituted 3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors, which have potential as antidiabetic agents, is described. Initial members of the series showed good enzyme inhibitory potency but poor physical properties. Optimisation of the 1-substituent led to 2,3-dihydroxypropyl compounds which showed good in vitro potency and improved physical properties, together with good DMPK profiles and acute in vivo efficacy in a rat model. X-ray crystallographic data are presented, showing an unexpected variety of binding orientations at the dimer interface site.