923573-22-2Relevant academic research and scientific papers
MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90
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Page/Page column 177, (2010/11/30)
Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.
Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases
Moulin, Emilie,Barluenga, Sofia,Totzke, Frank,Winssinger, Nicolas
, p. 8819 - 8834 (2007/10/03)
Pochonins A-F were recently characterized as six new members of the naturally occurring family of 14membered resorcylic acid lactones. As there are a high number of ATPase and kinase inhibitors among natural resorcylic lactones, a library based on the poc
