923601-79-0Relevant academic research and scientific papers
1-AMINO LINKED COMPOUNDS
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Page/Page column 38; 49-50, (2010/11/25)
The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C2-C6 alkyl-O- C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C2-C6 alkyl, -C(O)R9 and -SO2R9, or R7 and R8 combine to form (III), (IV); W is selected from CRlO and CR15, RlO is selected from H, halo, -C(O)NR13R14, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C1-C6 alkyl-O- C1-C6 alkyl and hydroxy C1-C6 alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH3, CF3, aryl, heteroaryl, C1-C4 alkylaryl or C1-C4 alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
