923688-65-7Relevant academic research and scientific papers
Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions
Breitler, Simon,Oldenhuis, Nathan J.,Fors, Brett P.,Buchwald, Stephen L.
supporting information; experimental part, p. 3262 - 3265 (2011/08/07)
A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.
Parallel synthesis of ureas and carbamates from amines and CO2 under mild conditions
Peterson, Scott L.,Stucka, Sabrina M.,Dinsmore, Christopher J.
supporting information; experimental part, p. 1340 - 1343 (2010/06/15)
"Chemical Equation Presented" A mild and efficient library synthesis technique has been developed for the synthesis of ureas and carbamates from carbamic acids derived from the DBU-catalyzed reaction of amines and gaseous carbon dioxide. Carbamic acids derived from primary amines reacted with Mitsunobu reagents to generate isocyanates in situ which were condensed with primary and secondary amines to afford the desired ureas. Similarly, carbamic acids from secondary amines reacted with alcohols activated with Mitsunobu reagents to form carbamates.
