923876-29-3Relevant academic research and scientific papers
Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity
Voskoboynik, Olexii Y.,Kovalenko, Sergiy I.,Shishkina, Svetlana V.
, p. 137 - 141 (2016)
The synthesis and antitumor activity of substituted benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones-novel electro-deficient tricyclic compounds-are described. These compounds were prepared by treatment of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with sodium nitrite in acetic acid. Spectral properties of synthesized compounds were studied and compared with spectral data of known 3-R-8-R1-10-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. These compounds are promising antitumor agents. The most active anticancer compound 3d was studied in dose-depended anticancer activity assay and its selective growth inhibition against breast cancer MDA-MB-468 cell line was established (GI50=0.41 μm).
Interaction of 3-(2-Aminophenyl)-6-R1-1,2,4-triazin-5-ones with Acylating Reagents: An Efficient Method for Preparation of 6-Substituted 3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones
Voskoboynik, Alexey Yu.,Scorina, Dmitriy Yu.,Sergeieva, Tetiana Yu.,Kovalenko, Sergiy I.,Okovytyy, Sergiy I.,Omelchenko, Irina V.,Shishkin, Oleg V.
, p. 776 - 783 (2016/05/19)
The series of 6-substituted 3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one was prepared via condensation of 3-(2-aminophenyl)-6-R1-1,2,4-triazin-5-ones with acylating reagents. Particularities of 1H NMR spectra have been also discussed based on the comparison of experimental and theoretical results for 3-methyl-6-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one and its 4,3-isomer.
