923958-35-4Relevant academic research and scientific papers
Synthesis of functionalized carboranes as potential anticancer and BNCT agents
Reddy, Venkata Jaganmohan,Roforth, Matthew M.,Tan, Chalet,Reddy, M. Venkat Ram
, p. 381 - 383 (2008/10/09)
Carboranyl aldehydes react with α,β-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.
