923974-25-8

Basic information

• Product Name: (2R,11aS)-2-hydroxy-10-(4-nitrobenzyl)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione
• Synonyms: (2R,11aS)-2-hydroxy-10-(4-nitrobenzyl)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione
• CAS NO: 923974-25-8
• Molecular Weight: 367.361
• Mol File: 923974-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,11aS)-2-hydroxy-10-(4-nitrobenzyl)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,11aS)-2-hydroxy-10-(4-nitrobenzyl)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione(923974-25-8)
• EPA Substance Registry System: (2R,11aS)-2-hydroxy-10-(4-nitrobenzyl)-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione(923974-25-8)

Safety Data

• Hazardous Substances Data: 923974-25-8(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 50424-51-6 (2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Relevant articles and documents

Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5, 11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors

A series of novel 10-substituted 2-hydroxypyrrolobenzodiazepine-5,11-diones designed through structure based rational hybridization approach, synthesized by the cyclodehydration of isotonic anhydride with (2S,4R)-4-hydroxypyrrolidine- 2-carboxylic acid followed by N-substitution, were evaluated as angiotensin converting enzyme (ACE) inhibitors. Among all the new compounds screened (2R,11aS)-10-((4-bromothiophen-2-yl)methyl)-2-hydroxy-2,3-dihydro-1H-benzo[e] pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)dione, 5v (IC50: 0.272 μM) emerged as most active non-carboxylic acid ACE inhibitor with minimal toxicity comparable to clinical drugs Lisinopril, Benazepril and Ramipril. Favorable binding characteristics in docking studies also supported the experimental results.