92402-25-0Relevant academic research and scientific papers
N2,N2′-disubstituted oxalic acid bishydrazides: Novel ligands for copper-catalyzed Ci￡N coupling reactions in water
Meng, Fei,Wang, Chenxia,Xie, Jianwei,Zhu, Xinhai,Wan, Yiqian
experimental part, p. 341 - 347 (2012/05/04)
A series of N2,N2′-disubstituted oxalic acid bishydrazides were synthesized. Some, for example, N2,N 2′-di-1-(4-methoxyphenyl)-ethanyloxylic-(bishydrazide), are novel and effective ligands for copper-catalyzed Ullmann-type Ci￡N coupling reaction in water. A variety of amines could be effectively N-arylated with aryl halides under both microwave irradiation and conventional heating (even at 30 °C) with good to excellent yields.
Efficient copper-catalyzed direct amination of aryl halides using aqueous ammonia in water
Meng, Fei,Zhu, Xinhai,Li, Ying,Xie, Jianwei,Wang, Bo,Yao, Junhua,Wan, Yiqian
supporting information; experimental part, p. 6149 - 6152 (2010/12/29)
The N2,N2′-diisopropyloxalohydrazide/CuO system efficiently catalyzed the direct amination of aryl bromides andiodides with aqueous ammonia in water at 60 °C in 24 h or at 120 °C in only 20-30 min. Both activated and unactivated aryl and heteroaryl bromides and iodides were readily aminated in good to excellent yields. A highly efficient N 2,N2′-diisopropyloxalohydrazide/CuO system was developed for the direct amination of aryl halides with aqueous ammonia in water at 60 °C for24 h or at 120 °C for 20-30 min. The resulting aromatic primary amines were obtained in good to excellent yields.
