92406-39-8

Upstream product

• 95882-33-0 3-cyclopentyl-3-oxopropanenitrile 
• 60-34-4 methylhydrazine 

Downstream Products

• 118432-12-5 3-Cyclopentyl-1,6-dimethyl-4-phenyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride 
• 118431-56-4 3-cyclopentyl-1,6-dimethyl-4-(3-nitrophenyl)pyrazolo<3,4-b>pyridine 
• 92406-55-8 3-Cyclopentyl-1,6-dimethyl-4-(3-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; hydrochloride 
• 92406-16-1 4-(2-Chloro-phenyl)-3-cyclopentyl-1,6-dimethyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; hydrochloride 
• 118432-01-2 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; hydrochloride 
• 118431-55-3 3-cyclopentyl-1,6-dimethyl-4-(3-nitrophenyl)pyrazolo<3,4-b>pyridine-5-carboxylic acid 
• 118431-54-2 methyl 3-cyclopentyl-1,6-dimethyl-4-(3-nitrophenyl)pyrazolo<3,4-b>pyridine-5-carboxylate 
• 118431-48-4 methyl 4-(3-aminophenyl)-3-cyclopentyl-4,7-dihydro-1,6-dimethylpyrazolo<3,4-b>pyridine-5-carboxylate 
• 118432-04-5 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(3-trifluoromethyl-phenyl)-ethyl ester; hydrochloride 
• 118432-05-6 3-Cyclopentyl-1,6-dimethyl-4-(3-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(3,4-dimethoxy-phenyl)-ethyl ester; hydrochloride 
• 118432-08-9 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-phenyl-piperidin-1-yl)-ethyl ester; hydrochloride 
• 100287-34-1 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(3,4-dimethoxy-phenyl)-ethyl ester; hydrochloride 
• 118432-02-3 3-Cyclopentyl-1,6-dimethyl-4-(3-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester; hydrochloride 
• 118432-03-4 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-bromo-phenyl)-ethyl ester; hydrochloride 

Relevant academic research and scientific papers

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.

4,7-dihydropyrazolo(3,4-b) pyridine derivatives

Novel Ca-blockers, 4,7-dihydropyrazolo[3,4-b]pyridine derivatives having potent antihypertensive and coronary vasodilating actions and useful in treatment for diseases in circulatory system, but without systole inhibitory action.