92406-42-3

Basic information

• Product Name: 1H-Pyrazol-5-amine, 3-cyclohexyl-1-methyl-
• CAS NO: 92406-42-3
• Molecular Formula: C10H17N3
• Molecular Weight: 179.265
• Mol File: 92406-42-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazol-5-amine, 3-cyclohexyl-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazol-5-amine, 3-cyclohexyl-1-methyl-(92406-42-3)
• EPA Substance Registry System: 1H-Pyrazol-5-amine, 3-cyclohexyl-1-methyl-(92406-42-3)

Safety Data

• Hazardous Substances Data: 92406-42-3(Hazardous Substances Data)

Usage

Chemical class

Pyrazole amines

Common uses

Building block for the preparation of various pharmaceuticals and agrochemicals

Structural features

Contains a pyrazole ring, a cyclohexyl group, and a methyl group

Stability and flexibility

Provided by the cyclohexyl and methyl groups for use in diverse chemical reactions and applications.

Upstream product

• 62455-70-3 3-cyclohexyl-3-oxopropanenitrile 
• 60-34-4 methylhydrazine 

Downstream Products

• 100287-22-7 3-Cyclohexyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-phenoxy-ethyl ester; hydrochloride 
• 118431-15-5 4,7-dihydro-1,6-dimethyl-4-(2-nitrophenyl)-3-(cyclohexyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester 

Relevant articles and documents

HSP90 INHIBITORS AND USES THEREOF

Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related deseases.

HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.