92411-00-2

Basic information

• Product Name: Boc-Pro-Gly-Pro-OBzl
• Synonyms: Boc-Pro-Gly-Pro-OBzl
• CAS NO: 92411-00-2
• Molecular Weight: 459.543
• Mol File: 92411-00-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Boc-Pro-Gly-Pro-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Pro-Gly-Pro-OBzl(92411-00-2)
• EPA Substance Registry System: Boc-Pro-Gly-Pro-OBzl(92411-00-2)

Safety Data

• Hazardous Substances Data: 92411-00-2(Hazardous Substances Data)

Upstream product

• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 57294-31-2 tert-butyl (S)-2-((2-ethoxy-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 51785-82-1 N-tert-butyloxycarbonyl-L-prolylglycine 
• 83610-54-2 glycyl-L-proline benzyl ester trifluoroacetate 

Downstream Products

• 7561-51-5 Pro-Gly-Pro 
• 92411-05-7 Boc-Met-γ-Bzl-Glu-His-Phe-Pro-Gly-Pro-OBzl 
• 80714-61-0 H-Met-Glu-His-Phe-Pro-Gly-Pro 
• 92411-04-6 Boc-γ-Bzl-Glu-His-Phe-Pro-Gly-Pro-OBzl 
• 92411-06-8 Boc-Met-Glu-His-Phe-Pro-Gly-Pro 
• 92411-03-5 Boc-His-Phe-Pro-Gly-Pro-OBzl 

Relevant articles and documents

METHOD FOR PRODUCING RECOMBINANT PEPTIDE AND RESULTANT PEPTIDE

PROBLEM TO BE SOLVED: To provide peptides with reproductive- and sexual-function stimulating activity. SOLUTION: The peptides are represented by general formula: A-Thr-Lys-Pro-B-C-D-X (where A is 0, Met, Met(O), Thr, Ala, His, Phe, Lys, or Gly; B is 0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, or Arg; C is 0, Arg, Phe, Tyr, Gly, His, Pro, or Lys; D is 0, Val, Gly, Tyr, Trp, Phe, or His; and X is OH, OCH3, or NH2; where 0 represents absence of the amino acid residue; provided that if A≠0 then B ≠0 and/or C≠0 and/or D≠0, if B≠0 then C≠0 and/or D≠0, and peptides Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg and Thr-Lys-Pro-Arg-Gly are excluded). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPO&INPIT

Stability of His-Phe-Arg-Trp-Pro-Gly-Pro to Leucine Aminopeptidase, Carboxypeptidase Y, and Rat Nasal Mucus, Blood, and Plasma

The His-Phe-Arg-Trp-Pro-Gly-Pro [ACTH-(6-9)-PGP] peptide was synthesized. Proteolysis of ACTH-(6-9)-PGP and semax (Met-Glu-His-Phe-Pro-Gly-Pro) in the presence of leucine aminopeptidase and carboxypeptidase Y was studied. If the proteolysis of ACTH-(6-9)-PGP is mainly defined by aminopeptidases, the basic metabolite is Trp-Pro-Gly-Pro. Identification of major metabolites of ACTH-(6-9)PGP when incubated with the enzymes in vitro made it possible to evaluate proteolysis pathways of the peptide and prepare necessary amounts of its metabolites for using them as standards. Kinetics of ACTH-(6-9)PGP degradation in the presence of enzyme systems of nasal mucus, blood, and plasma were also explored. It was found that proteolysis of ACTH-(6-9)-PGP in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase.

AN ANALOG OF ACTH4-10 - A LONG-ACTION STIMULATOR OF LEARNING

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