92412-67-4Relevant academic research and scientific papers
Identification of novel, selective and potent Chk2 inhibitors
Larson, Gary,Yan, Shunqi,Chen, Huanming,Rong, Frank,Hong, Zhi,Wu, Jim Zhen
, p. 172 - 175 (2007/10/03)
A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, an
4-/TRANS-4'-n-ALKYLCYCLOHEXYL/ISOTHIOCYANATOBENZENES A NEW CLASS OF LOW-MELTING STABLE NEMATICS
Dabrowski, R.,Dziaduszek, J.,Szczucinski, T.
, p. 155 - 160 (2007/10/02)
The mesogenic properties of four series of compounds with the isothiocyanate terminal group are compared, viz.: 4-n-alkyl-4'-isothiocyanatobiphenyls /1/, 4-/trans-4'-n-alkyl-cyclohexyl/benzeneisothiocyanates /2/, isothiocyanatophenyl 4-n-alkylbenzoates /3/ and isothiocyanatophenyl 4-/trans-4'-n-alkylcyclohexyl/benzoates /4/.It has been found that compounds 2 have only the nematic phase in the homologous series from 2 to 10 carbon atom in the alkyl chain, and compounds 4 the nematic and smectic A phases, while the so far know compounds 1 and 3 are E or A smectics.
