924312-16-3Relevant academic research and scientific papers
Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
Ando, Makoto,Sekino, Etsuko,Haga, Yuji,Moriya, Minoru,Ito, Masahiko,Ito, Junko,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Ohtake, Norikazu
scheme or table, p. 5186 - 5190 (2010/03/24)
Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives.
PYRIDONE COMPOUND
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Page/Page column 35, (2010/11/30)
An active ingredient is a compound represented by the general formula [I]: [wherein R1 and R2 represent a lower alkyl group, a C3-6 cycloalkyl group or the like, X1 and X2 represent methine, an Ar-Ys
