92435-82-0Relevant academic research and scientific papers
Copper-Catalyzed Vicinal Chloro-thiolation of Alkynes with Sulfonyl Chlorides
Liang, Shuaishuai,Jiang, Lvqi,Yi, Wen-Bin,Wei, Jingjing
supporting information, p. 7024 - 7028 (2018/11/21)
A copper-catalyzed vicinal chloro-thiolation of alkynes with inexpensive and diversified sulfonyl chlorides RSO2Cl (R = aryl, alkyl) has been developed. This practical and scalable reaction could be used for the construction of a number of unexplored bioactive chlorothiolated alkenes. Internal alkynes could also undergo the chloro-thiolation to provide tetrasubstituted alkynes. Preliminary mechanistic investigations revealed a plausible radical process involving a sulfur-centered radical intermediate via copper-mediated homolysis of the S-Cl bond.
