92445-35-7Relevant academic research and scientific papers
PYRYLIUM-MEDIATED TRANSFORMATIONS OF NATURAL PRODUCTS. PART 7. DISPLACEMENT OF THE N-SUBSTITUENTS OF PYRIDINIUM IONS IN AQUEOUS SOLUTION: REPLACEMENT OF THE ω-AMINO GROUP OF LYSINE, AND OF THE TERMINAL AMINO GROUP OF GLYCYLGLYCINE
Katritzky, Alan R.,Yang, Yu-Kun
, p. 885 - 890 (2007/10/02)
In two-step sequences, lysine has been converted into the thio-substituted derivatives RS4CH(NH2)CO2H (R=Ph or PhCH2), and glycylglycine into PhSCH2CONHCH2CO2H.All reactions proceeded in aqueous solution at /= 75 deg C; they thus provide models for the selective conversion of proteins at the ω-amino groups of lysine side chains and at the terminal amino groups, respectively.
