92447-22-8

Upstream product

• 591-35-5 3,5-dichlorophenol 
• 92447-18-2 Methoxy-acetic acid (2R,3S,5R)-5-[2-amino-6-(2,4,6-trimethyl-benzenesulfonyloxy)-purin-9-yl]-2-(2-methoxy-acetoxymethyl)-tetrahydro-furan-3-yl ester 
• 92447-17-1 3',5'-di-O-methoxyacetyl-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 19500-95-9 Methoxyacetic anhydride 

Downstream Products

• 92447-24-0 6-O-(3,5-dichlorophenyl)-2-N-phenylacetyl-5'-O-(9-phenyl-9H-xanthen-9-yl)-2'-deoxyguanosine 
• 92447-23-9 6-O-(3,5-dichlorophenyl)-2-N-phenylacetyl-2'-deoxyguanosine 
• 92447-25-1 N²-Phenylacetyl-2'-deoxyguanosine 

Relevant academic research and scientific papers

The Protection of Thymine and Guanine Residues in Oligodeoxyribonucleotide Synthesis

Thymidine is converted in four steps into its crystalline 4-O-phenyl derivative (14b) in 72percent overall yield. 2'-Deoxyguanosine is converted in five steps into its 6-O-(2-nitrophenyl)-2-N-phenylacetyl and crystalline 6-O-(3,5-dichlorophenyl)-2-N-phenylacetyl derivatives in ca. 39 and 42percent overall yields, respectively.Compounds (14b), (19a), and (19b) are converted into the corresponding crystalline 5'-O-(9-phenyl-9H-xanthen-9-yl) derivatives (15), (20a), and (20b), respectively.The actions of N1,N1,N3,N3-tetramethylguanidinium 2-nitrobenzaldehyde oximate, 80percent acetic acid, potassium carbonate in aqueous dioxane, pyridine, and triethylammonium toluene-p-thiolate on (14b), (19a), and (19b) have been investigated.