924635-05-2 Usage
Molecular structure
1H-Indole-1-carboxylic acid, 3-(3-chloro-2-oxopropyl)-5-methoxy-, phenylmethyl ester is a chemical compound derived from the indole core structure, with various substituents attached to it.
Indole core
The compound is based on a heterocyclic organic compound, indole, which consists of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.
Methoxy group
The compound contains a methoxy (-OCH3) group attached to the indole core, which is a methoxy substituent that can influence the compound's solubility, stability, and biological activity.
Chloro-substituted oxopropyl group
A 3-chloro-2-oxopropyl group (-CHCl-CH2-CO-) is attached to the indole core, which introduces a chlorine atom and an oxopropane moiety to the compound, potentially affecting its pharmacokinetic and pharmacodynamic properties.
Phenylmethyl ester group
The compound features a phenylmethyl ester (-COOCH2-C6H5) group, which is an ester formed from the carboxylic acid function of the indole core and a phenylmethyl alcohol.
Biological activities
1H-Indole-1-carboxylic acid, 3-(3-chloro-2-oxopropyl)-5-methoxy-, phenylmethyl ester has demonstrated potential in various biological activities, such as anti-inflammatory, anti-cancer, and anti-viral properties.
Potential applications
Due to its biological activities, the compound has potential applications in pharmaceuticals and research, particularly in the fields of medicine and drug discovery.
Further study and development
The compound is a target for further study and development to better understand its properties, efficacy, and safety, and to explore its potential as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 924635-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,4,6,3 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 924635-05:
(8*9)+(7*2)+(6*4)+(5*6)+(4*3)+(3*5)+(2*0)+(1*5)=172
172 % 10 = 2
So 924635-05-2 is a valid CAS Registry Number.
924635-05-2Relevant academic research and scientific papers
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H] quinoline-4-carboxylic acid (PSI-697): Identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists
Kaila, Neelu,Janz, Kristin,Huang, Adrian,Moretto, Alessandro,DeBernardo, Silvano,Bedard, Patricia W.,Tam, Steve,Clerin, Valerie,Keith Jr., James C.,Tsao, Desirée H.H.,Sushkova, Natalia,Shaw, Gray D.,Camphausen, Raymond T.,Schaub, Robert G.,Wang, Qin
, p. 40 - 64 (2007/10/03)
P-selectin-PSGL-1 interaction causes rolling of leukocytes on the endothelial cell surface, which subsequently leads to firm adherence and leukocyte transmigration through the vessel wall into the surrounding tissues. P-selectin is upregulated on the surface of both platelets and endothelium in a variety of atherosclerosis-associated conditions. Consequently, inhibition of this interaction by means of a small molecule P-selectin antagonist is an attractive strategy for the treatment of atherosclerosis. High-throughput screening and subsequent analoging had led to the identification of compound 1 as the lead candidate. Herein, we report the continuation of this work and the discovery of a second-generation series, the tetrahydrobenzoquinoline salicylic acids. These compounds have improved pharmacokinetic properties, and a number of them have shown oral efficacy in mouse and rat models of atherogenesis and vascular injury. The lead 31 (PSI-697), is currently in clinical development for the treatment of atherothrombotic vascular events.
