92469-35-7

Basic information

• Product Name: 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine
• Synonyms: 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine;5-(4-Methoxyphenyl)-2-Methylpyrazol-3-aMine
• CAS NO: 92469-35-7
• Molecular Formula: C₁₁H₁₃N₃O
• Molecular Weight: 203.24
• Mol File: 92469-35-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 140-141 ºC
• Boiling Point: 401.6 °C at 760 mmHg
• Flash Point: 196.7 °C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 1.17E-06mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine(92469-35-7)
• EPA Substance Registry System: 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine(92469-35-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 92469-35-7(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine is an organic chemical compound with the molecular formula C11H13N3O. It is a pyrazole derivative with a methyl group and an aminophenyl substituent. 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine is often used in pharmaceutical research and drug discovery as a potential candidate for the development of new medications. Additionally, it may have applications in the field of organic synthesis and as a building block for the construction of more complex molecules. Its properties and potential uses make it a valuable and important chemical in various scientific and industrial applications.

InChI:InChI=1/C11H13N3O/c1-14-11(12)7-10(13-14)8-3-5-9(15-2)6-4-8/h3-7H,12H2,1-2H3

Upstream product

• 60-34-4 methylhydrazine 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 57466-68-9 3-chloro-3-(4-methoxyphenyl)acrylonitrile 

Downstream Products

• 1415484-55-7 C₂₆H₃₀N₆O₂ 
• 126418-07-3 N-[5-(4-Methoxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

HSP90 INHIBITORS AND USES THEREOF

Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related deseases.

Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors

In anaplastic large-cell lymphomas, chromosomal translocations involving the kinase domain of anaplastic lymphoma kinase (ALK), generally fused to the 5' part of the nucleophosmin gene, produce highly oncogenic ALK fusion proteins that deregulate cell cycle, apoptosis, and differentiation in these cells. Other fusion oncoproteins involving ALK, such as echinoderm microtubule-associated protein-like 4-ALK, were recently found in patients with non-small-cell lung, breast, and colorectal cancers. Recent research has focused on the development of inhibitors for targeted therapy of these ALK-positive tumors. Because kinase inhibitors that target the inactive conformation are thought to be more specific than ATP-targeted inhibitors, we investigated the possibility of using two known inhibitors, doramapimod and sorafenib, which target inactive kinases, to design new urea derivatives as ALK inhibitors. We generated a homology model of ALK in its inactive conformation complexed with doramapimod or sorafenib in its active site. The results elucidated why doramapimod is a weak inhibitor and why sorafenib does not inhibit ALK. Virtual screening of commercially available compounds using the homology model of ALK yielded candidate inhibitors, which were tested using biochemical assays. Herein we present the design, synthesis, biological activity, and structure-activity relationships of a novel series of urea compounds as potent ALK inhibitors. Some compounds showed inhibition of purified ALK in the high nanomolar range and selective antiproliferative activity on ALK-positive cells.