92471-87-9Relevant articles and documents
Total synthesis of (+)-tedanolide
Smith III, Amos B.,Lee, Dongjoo
, p. 10957 - 10962 (2007)
A convergent, stereocontrolled total synthesis of (+)-tedanolide (1), an architecturally complex marine antitumor macrolide, has been achieved in 31 steps (longest linear sequence). Highlights of the synthesis comprise a highly efficient dithiane union, f
The total synthesis of (+)-tedanolide - A macrocyclic polyketide from marine sponge tedania ignis
Ehrlich, Gunnar,Hassfeld, Jorma,Eggert, Ulrike,Kalesse, Markus
experimental part, p. 2232 - 2247 (2009/04/07)
Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis, is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in bioassays. A unique structural feature of the known tedanolides is the prima
