924727-16-2Relevant academic research and scientific papers
Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
Klar, Ulrich,Buchmann, Bernd,Schwede, Wolfgang,Skuballa, Werner,Hoffmann, Jens,Lichtner, Rosemarie B.
, p. 7942 - 7948 (2007/10/03)
Going to trial: From about 350 active epothilone analogues synthesized by a highly convergent synthesis, one (ZK-EPO, see picture) has been chosen for clinical development on the basis of its outstanding preclinical data. This compound exhibits higher activity and efficacy than taxanes (e.g. paclitaxel) and second-generation epothilones, a fast and efficient cellular uptake, no recognition by efflux mechanisms, and an improved therapeutic window. (Chemical Equation Presented)
