92486-98-1

Usage

Structure

Pyridine ring with substituents including an amino group, a chlorophenyl group, and a dimethylamino group

Functional group

Carbonitrile

Potential applications

Medicinal chemistry, agrochemicals, materials science

Upstream product

• 92486-95-8 4,4-Dicyano-3-dimethylamino-but-3-enethioic acid (4-chloro-phenyl)-amide 
• 92486-89-0 (Z)-N-(4-Chloro-phenyl)-3-dimethylamino-3-methylsulfanyl-thioacrylamide 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Ketene-S,N-acetals as Synthetic Intermediates for Heterocycles. New Synthesis of Multisubstituted Pyridine-2-thiones

Ketene-S,N-acetals reacted with isothiocyanates to give β-aminothiocarbonyl-α-methylthioenamines, which were transformed into enaminonitriles by carbon-carbon bond formation with malononitriles.Treatment of the enaminonitriles with base afforded pyridine-

KETENE-S,N-ACETALS AS SYNTHETIC INTERMEDIATES FOR HETEROCYCLES. A NOVEL SYNTHESIS OF POLYFUNCTIONALIZED PYRIDINE-2-THIONES

A new synthesis of polyfunctionalized pyridine-2-thiones (4a-c) by the carbon-carbon bond formation between β-aminothiocarbonyl-α-methylthioenamines (3a-c) derived from ketene-S,N-acetal (1) and malononitrile as a carbon nucleophile is described.In additi