924863-99-0

Basic information

• Product Name: 2-[5-(4-dimethylamino-benzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide
• CAS NO: 924863-99-0
• Molecular Weight: 432.402
• Mol File: 924863-99-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[5-(4-dimethylamino-benzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-(4-dimethylamino-benzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide(924863-99-0)
• EPA Substance Registry System: 2-[5-(4-dimethylamino-benzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide(924863-99-0)

Safety Data

• Hazardous Substances Data: 924863-99-0(Hazardous Substances Data)

Upstream product

• 3792-04-9 2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide 
• 10040-87-6 5-(4-dimethylaminobenzylidene)imidazolidine-2,4-dione 

Relevant articles and documents

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

The synthesis and evaluation of anticancer activity of 2,4-thia(imida)zolidinedione-3- and 5-acetic acids amides were described. The structures of compounds were determined by IR, 1H NMR, and MS analysis. In vitro anticancer activity of these compounds has been tested in National Cancer Institute (NCI) and the relationships between structure and anticancer activity are discussed. Among 2,4-azolidinedione-acetic acids derivatives 2-[5-(4-chlorobenzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide (Ic) was superior to other related compounds in terms of high selectivity for the leukemia CCRF-CEM (log GI50 = -6.06), HL-60(TB) (log GI50 = -6.53), MOLT-4 (log GI50 = -6.52) and SR (log GI50 = -6.51) cell lines.