924893-94-7Relevant academic research and scientific papers
Lipase-catalyzed kinetic resolution of 2-phenylethanol derivatives and chiral oxa-Pictet-Spengler reaction as the key steps in the synthesis of enantiomerically pure tricyclic amines
Ketterer, Christian,Wuensch, Bernhard
, p. 2428 - 2444 (2012/06/01)
A series of 5,6,7,8,9,10-hexahydro-5,9-epoxybenzocycloocten-6-amines have been synthesized and pharmacologically evaluated in receptor binding studies (σ1, σ2, NMDA, κ, and μ receptors). The first key step of the synthesis was a chir
Chemoenzymatic synthesis of enantiomerically pure tricyclic benzomorphan analogues
Ketterer, Christian,Grimme, Stefan,Weckert, Edgar,Wuensch, Bernhard
, p. 3046 - 3050 (2007/10/03)
The key step in the synthesis of enantiomerically pure benzomorphan analogous tricyclic amines 2 is the kinetic resolution of secondary alcohol 7 using the lipase from Pseudomonas fluorescence. The (S)-configured alcohol (S)-7 and the (R)-configured ester
