92493-10-2Relevant articles and documents
Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines
Pettersson, Fredrik,Svensson, Peder,Waters, Susanna,Waters, Nicholas,Sonesson, Clas
, p. 241 - 255 (2013/06/04)
A series of mono-substituted 4-phenylpiperidines and -piperazines have been synthesized and their effects on the dopaminergic system tested in vivo. The structure activity relationship (SAR) revealed that the position and physicochemical character of the
Structure-Activity Relationship Studies of Central Nervous System Agents. 13. 4--1-(2-methoyphenyl)piperazine, a new Putative 5HT1A Receptor Antagonist, and Its Analogs
Mokrosz, Jerzy L.,Paluchowska, Maria H.,Chojnacka-Wojcik, Ewa,Filip, Malgorzata,Charakchieva-Minol, Sijka,et al.
, p. 2754 - 2760 (2007/10/02)
A new set of 4-alkyl-1-(o-methoxyphenyl)piperazines containing a terminal benzotriazole fragment were synthesized, and their 5-HT1A and 5-HT2 affinity was determined.It was shown that the benzotriazole moiety contributes to both the