925231-82-9

Upstream product

• 925231-66-9 methoxymethoxy-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-acetaldehyde 
• 925231-64-7 hydroxy-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-acetic acid ethyl ester 
• 925231-65-8 methoxymethoxy-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-acetic acid ethyl ester 
• 925231-73-8 [5-(1-methoxymethoxy-3-methyl-2-triisopropylsilanyloxy-pent-4-enyl)-tetrahydro-furan-2-yl]-acetic acid ethyl ester 
• 925231-75-0 [5-(1-methoxymethoxy-3-methyl-5-oxo-2-triisopropylsilanyloxy-pentyl)-tetrahydro-furan-2-yl]-acetic acid ethyl ester 
• 925231-68-1 triisopropyl-(1-{methoxymethoxy-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-methyl}-2-methyl-but-3-enyloxy)-silane 
• 925231-74-9 [5-(5-hydroxy-1-methoxymethoxy-3-methyl-2-triisopropylsilanyloxy-pentyl)-tetrahydro-furan-2-yl]-acetic acid ethyl ester 
• 925231-70-5 toluene-4-sulfonic acid 3-hydroxy-4-methoxymethoxy-6-methyl-5-triisopropylsilanyloxy-oct-7-enyl ester 
• 925231-76-1 [5-(1-methoxymethoxy-3-methyl-2-triisopropylsilanyloxy-hex-5-ynyl)-tetrahydro-furan-2-yl]-acetic acid ethyl ester 
• 925231-79-4 [5-(1-methoxymethoxy-3,9-dimethyl-5-methylene-2-triisopropylsilanyloxy-deca-6,9-dienyl)-tetrahydro-furan-2-yl]-acetaldehyde 
• 925231-80-7 3-[5-(1-methoxymethoxy-3,9-dimethyl-5-methylene-2-triisopropylsilanyloxy-deca-6,9-dienyl)-tetrahydro-furan-2-yl]-propionaldehyde 
• 925231-77-2 [5-(1-methoxymethoxy-3,9-dimethyl-5-methylene-2-triisopropylsilanyloxy-deca-6,9-dienyl)-tetrahydro-furan-2-yl]-acetic acid ethyl ester 
• 848691-96-3 ethyl (2R,3S)-2,3-dihydroxy-5-((4-methoxybenzyl)oxy)pentanoate 

Relevant academic research and scientific papers

Total synthesis of (-)-amphidinolide E

The unique structural features of the cytotoxic marine macrolide (-)-amphidinolide E make it an intriguing synthetic target. Its total synthesis has now been completed by employing a radical cyclization of a β-alkoxy acrylate to form the oxolane ring, a Kocienski-Julia olefination to create the E C=C bond, and a lactonization reaction to close the macrocyclic ring. (Chemical Equation Presented).