925254-35-9Relevant academic research and scientific papers
Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells
Li, Jie,Kuang, Yi,Shi, Junfeng,Zhou, Jie,Medina, Jamie E.,Zhou, Rong,Yuan, Dan,Yang, Cuihong,Wang, Huaimin,Yang, Zhimou,Liu, Jianfeng,Dinulescu, Daniela M.,Xu, Bing
supporting information, p. 13307 - 13311 (2015/11/09)
Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug-resistant cancers without increasing the systemic toxicity. Here we show the use of enzyme-instructed self-assembly (EISA) to generate intracellular supramolecular assemblies that drastically boost the activity of cisplatin against drug-resistant ovarian cancer cells. We design and synthesize small peptide precursors as the substrates of carboxylesterase (CES). CES cleaves the ester bond pre-installed on the precursors to form the peptides that self-assemble in water to form nanofibers. At the optimal concentrations, the precursors themselves are innocuous to cells, but they double or triple the activity of cisplatin against the drug-resistant ovarian cancer cells. This work illustrates a simple, yet fundamental, new way to introduce non-cytotoxic components into combination therapies with cisplatin without increasing the systemic burden or side effects. Cisplatin-boosting nanofibers: The design and synthesis is reported of small peptide precursors that can be cleaved by carboxylesterase (CES) to form peptides that self-assemble in water to form molecular nanofibers. The precursors themselves are innocuous to cells at optimal concentrations, but they double or triple the activity of cisplatin against drug-resistant ovarian cancer cells.
Versatile small-molecule motifs for self-assembly in water and the formation of biofunctional supramolecular hydrogels
Zhang, Ye,Kuang, Yi,Gao, Yuan,Xu, Bing
body text, p. 529 - 537 (2012/02/14)
This feature article introduces new structural motifs (referred as "samogen") that serve as the building blocks of hydrogelators for molecular self-assembly in water to result in a series of supramolecular hydrogels. Using a compound that consists of two
Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules
Liang, Gaolin,Xu, Keming,Li, Lihua,Wang, Ling,Kuang, Yi,Yang, Zhimou,Xu, Bing
, p. 4096 - 4098 (2008/09/16)
This communication reports the use of Congo red to stain the nanofibers of self-assembled small molecules for assaying intracellular supramolecular hydrogels, which provides a convenient method to explore molecular self-assembly inside cells. The Royal So
