92532-77-9Relevant academic research and scientific papers
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1(A)/D2 affinity as potential atypical antipsychotics
Taverne, Thierry,Diouf, Ousmane,Depreux, Patrick,Poupaert, Jacques H.,Lesieur, Daniel,Guardiola-Lema?tre, Béatrice,Renard, Pierre,Rettori, Marie-Claire,Caignard, Daniel-Henri,Pfeiffer, Bruno
, p. 2010 - 2018 (2007/10/03)
Since it was known that 5HT properties (5HT(1A) agonism or 5HT(2A) antagonism) combined with D2 antagonism may lead to atypical antipsychotic drugs, a series of 19 benzothiazolin-2-one and benzoxazin-3-one derivatives possessing the arylpiperaz
Benzoxazolinones
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, (2008/06/13)
The invention relates to compounds of the formula: STR1 in which R represents hydrogen or a lower alkyl radical and R1 and R2 separately represent hydrogen, a lower alkyl, cycloalkyl or benzyl radical, or represent, together with the nitrogen atom to which they are bonded, a heterocyclic radical such as a morpholino, 4-(pyrimidin-2-yl)-piperazinyl or 4-phenylpiperazinyl the phenyl radical of which being optionally substituted by halogen, lower alkoxy or trifluoromethyl, having CNS activity and particularly hypnotic properties. Moreover the compounds in which R1 and R2 are hydrogen can be used in the treatment of heart failure.
