925422-53-3

Upstream product

• 925422-32-8 5-(pent-4-ynyl)-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine 
• 696-62-8 para-iodoanisole 
• 66927-74-0 5-bromo-1-(trimethylsilyl)pentyne 
• 925422-77-1 1-(toluene-4-sulfonyl)-3-(5-trimethylsilylpent-4-ynyl)piperidin-2-one 
• 925422-78-2 1-(toluene-4-sulfonyl)-5-(5-trimethylsilylpent-4-ynyl)-1,2,3,4-tetrahydropyridine 
• 925422-76-0 3-(5-trimethylsilylpent-4-ynyl)piperidin-2-one 
• 675-20-7 piperidin-2-one 

Relevant academic research and scientific papers

Enamides and enesulfonamides as nucleophiles: Formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway

(Chemical Equation Presented) Cyclic enamine derivatives (enesulfonamides and enamides) tethered to an 1-arylalkynyl fragment undergo a platinum(II)-catalyzed tandem alkyne addition/Friedel-Crafts ring closure to formnitrogen-containing polycyclic structures.Regioselectivity in the initial addition of the enesulfonamide or enamide nucleophile to the platinum(II)-alkyne complex is important. Electron-rich arenes and heterocycles led to the formation of products resulting from an initial 6-endo cyclization. Twenty-three examples of this process are presented.

Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles

(Chemical Equation Presented) Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more compl