925422-54-4Relevant articles and documents
Enamides and enesulfonamides as nucleophiles: Formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway
Kozak, Jennifer A.,Dodd, Jennifer M.,Harrison, Tyler J.,Jardine, Katherine J.,Patrick, Brian O.,Dake, Gregory R.
supporting information; experimental part, p. 6929 - 6935 (2009/12/06)
(Chemical Equation Presented) Cyclic enamine derivatives (enesulfonamides and enamides) tethered to an 1-arylalkynyl fragment undergo a platinum(II)-catalyzed tandem alkyne addition/Friedel-Crafts ring closure to formnitrogen-containing polycyclic structures.Regioselectivity in the initial addition of the enesulfonamide or enamide nucleophile to the platinum(II)-alkyne complex is important. Electron-rich arenes and heterocycles led to the formation of products resulting from an initial 6-endo cyclization. Twenty-three examples of this process are presented.
Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles
Harrison, Tyler J.,Patrick, Brian O.,Dake, Gregory R.
, p. 367 - 370 (2007/10/03)
(Chemical Equation Presented) Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more compl