925430-39-3Relevant academic research and scientific papers
Preparation method of L-phenylephrine hydrochloride
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Paragraph 0066-0077, (2020/10/04)
The invention relates to a preparation method of L-phenylephrine hydrochloride, and specifically discloses a preparation method of L-phenylephrine hydrochloride, which comprises the steps of chlorination reaction, chiral reduction reaction, amination salifying and recrystallization. The preparation method has the advantages of cheap and easily available raw materials, simple operation process, loweconomic cost, high product yield and the like, and the product quality meets the standard requirements of Chinese Pharmacopoeia and European Pharmacopoeia.
Asymmetric hydrogenation of α-chloro aromatic ketones catalyzed by η6-arene/TsDPEN-ruthenium(II) complexes
Ohkuma, Takeshi,Tsutsumi, Kunihiko,Utsumi, Noriyuki,Arai, Noriyoshi,Noyori, Ryoji,Murata, Kunihiko
, p. 255 - 257 (2007/10/03)
(Chemical Equation Presented) Asymmetric hydrogenation of various α-chloro aromatic ketones with Ru(OTf)(TsDPEN)(η6-arene) (TsDPEN = N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine) produces the chiral chlorohydrins in up to 98% ee. This reac
Practical synthesis of optically active styrene oxides via reductive transformation of 2-chloroacetophenones with chiral rhodium catalysts
Hamada, Takayuki,Torii, Takayoshi,Izawa, Kunisuke,Noyori, Ryoji,Ikariya, Takao
, p. 4373 - 4376 (2007/10/03)
(equation presented) A practical method for the synthesis of optically active styrene oxides has been developed via formation of optically active 2-chloro-1-phenylethanols generated by reductive transformation of ring-substituted 2-chloroacetophenones. Th
