925432-71-9Relevant academic research and scientific papers
Discovery of imidazo[1,2-6]thiazole derivatives as novel SIRT1 activators
Vu, Chi B.,Bemis, Jean E.,Disch, Jeremy S.,Ng, Pui Yee,Nunes, Joseph J.,Milne, Jill C.,Carney, David P.,Lynch, Amy V.,Smith, Jesse J.,Lavu, Siva,Lambert, Philip D.,Gagne, David J.,Jirousek, Michael R.,Schenk, Simon,Olefsky, Jerrold M.,Perni, Robert B.
experimental part, p. 1275 - 1283 (2009/12/07)
A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. This series of compounds was derived from a high throughput scree
