925437-85-0

Basic information

• Product Name: 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE
• Synonyms: 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE;6-(2-Nitrophenyl)-IMidazo[2,1-b]thiazole-3-Methanol;[6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]methanol
• CAS NO: 925437-85-0
• Molecular Formula: C₁₂H₉N₃O₃S
• Molecular Weight: 275.29
• Mol File: 925437-85-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.592g/cm³
• Refractive Index: 1.765
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.27±0.10(Predicted)
• CAS DataBase Reference: 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE(925437-85-0)
• EPA Substance Registry System: 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE(925437-85-0)

Safety Data

• Hazardous Substances Data: 925437-85-0(Hazardous Substances Data)

Usage

General Description

3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE is a chemical compound that belongs to the family of imidazothiazole derivatives. It is characterized by a 3-hydroxymethyl group and a 2-nitrophenyl group attached to the imidazothiazole ring structure. 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE has potential pharmacological applications as it exhibits antimicrobial and antifungal properties. It has also been studied for its potential use in the treatment of various diseases, including cancer. Furthermore, it has shown promise in the field of medicinal chemistry for the development of novel drugs and therapies. Overall, 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE is a versatile chemical with potential biomedical applications.

InChI:InChI=1/C12H9N3O3S/c16-6-8-7-19-12-13-10(5-14(8)12)9-3-1-2-4-11(9)15(17)18/h1-5,7,16H,6H2

Upstream product

• 925437-84-9 6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 
• 543-27-1 isobutyl chloroformate 
• 912770-13-9 6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid 

Downstream Products

• 1093403-37-2 C₁₃H₁₁N₃O₅S₂ 
• 925437-87-2 4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1093403-43-0 4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide 
• 1093403-44-1 6-(2-nitro-phenyl)-3-[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazole 
• 1093403-45-2 2-(3-[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenylamine 
• 925434-55-5 SRT1720 
• 925436-46-0 C₃₀H₃₁N₇O₃S 
• 1449583-94-1 C₁₃H₁₁N₃O₃S 
• 1449583-93-0 C₁₆H₁₇N₃O₅S 
• 1449583-96-3 C₁₈H₂₀N₄O₄S 
• 1449583-95-2 C₁₃H₁₂N₄O₂S 
• 925438-48-8 3-chloromethyl-6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole 
• 1056562-54-9 2-(3-morpholin-4-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenylamine 
• 1093403-33-8 SRT₂₁₀₄ 

Relevant articles and documents

Synthesis and Assay of SIRT1-Activating Compounds

The NAD+-dependent deacetylase SIRT1 plays key roles in numerous cellular processes including DNA repair, gene transcription, cell differentiation, and metabolism. Overexpression of SIRT1 protects against a number of age-related diseases including diabetes, cancer, and Alzheimer's disease. Moreover, overexpression of SIRT1 in the murine brain extends lifespan. A number of small-molecule sirtuin-activating compounds (STACs) that increase SIRT1 activity in vitro and in cells have been developed. While the mechanism for how these compounds act on SIRT1 was once controversial, it is becoming increasingly clear that they directly interact with SIRT1 and enhance its activity through an allosteric mechanism. Here, we present detailed chemical syntheses for four STACs, each from a distinct structural class. Also, we provide a general protocol for purifying active SIRT1 enzyme and outline two complementary enzymatic assays for characterizing the effects of STACs and similar compounds on SIRT1 activity.

Discovery of imidazo[1,2-6]thiazole derivatives as novel SIRT1 activators

A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. This series of compounds was derived from a high throughput scree

SIRTUIN POLYMORPHISMS AND METHODS OF USE THEREOF

Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound andor subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage andor treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.