92545-92-1Relevant academic research and scientific papers
Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene
Trifonov, Alexey L.,Dilman, Alexander D.
, p. 6977 - 6981 (2021)
A diversity-oriented and C2-selective synthesis of difluoroalkyl-substituted heteroarenes from three fragments, N-methoxyazinium salts, difluorocarbene, and electrophilic or radical reagents, is described. The reaction proceeds via the addition of difluorinated phosphorus ylide to in situ methylated heteroarene N-oxides, leading to phosphonium salts, which can undergo further transformations under basic or photoinduced conditions.
