92549-05-8Relevant academic research and scientific papers
Stilbene synthesis through decarboxylative cross-coupling of substituted cinnamic acids with aryl halides
Rameau, Nelly,Russo, Baptiste,Mangematin, Stéphane,Pinel, Catherine,Djakovitch, Laurent
, p. 132 - 143 (2018/05/22)
The Pd-catalyzed decarboxylative cross-coupling reaction between cinnamic acid and aryl iodide derivatives was studied using both homogeneous and heterogeneous Pd-catalysts. It was demonstrated that simple Pd(OAc)2 can catalyze this reaction wi
Organocatalytic asymmetric synthesis of 1,1-diarylethanes by transfer hydrogenation
Wang, Zhaobin,Ai, Fujin,Wang, Zheng,Zhao, Wanxiang,Zhu, Guangyu,Lin, Zhenyang,Sun, Jianwei
supporting information, p. 383 - 389 (2015/01/30)
A new organocatalytic transfer hydrogenation strategy for the asymmetric synthesis of 1,1-diarylethanes is described. Under mild conditions, a range of 1,1-diarylethanes substituted with an o-hydroxyphenyl or indole unit could be obtained with excellent efficiency and enantioselectivity. We also extended the protocol to an unprecedented asymmetric hydroarylation of 1,1-diarylalkenes with indoles for the synthesis of a range of highly enantioenriched 1,1,1-triarylethanes bearing acyclic all-carbon quaternary stereocenters. These diaryl- and triarylethanes exhibit impressive cytotoxicity against a number of human cancer cell lines. Preliminary mechanistic studies combined with DFT calculations provided important insight into the reaction mechanism.
Catalytic Asymmetric 1,6-Conjugate Addition of para-Quinone Methides: Formation of All-Carbon Quaternary Stereocenters
Wang, Zhaobin,Wong, Yuk Fai,Sun, Jianwei
supporting information, p. 13711 - 13714 (2015/11/11)
Described herein is a general and mild catalytic asymmetric 1,6-conjugate addition of para-quinone methides (p-QMs), a class of challenging reactions with previous limited success. Benefiting from chiral Bronsted acid catalysis, which allows in situ formation of p-QMs, our reaction expands the scope to general p-QMs with various substitution patterns. It also enables efficient intermolecular formation of all-carbon quaternary stereocenters with high enantioselectivity.
PALLADIUM-CATALYSED REDUCTIVE ADDITION OF ARYL IODIDES TO ARYL AND ALKYLETHYNYLSILANES: A STEREO AND REGIOSELECTIVE ROUTE TO FUNCTIONALIZED 2,2-DISUBSTITUTED VINYLSILANES
Arcadi, A.,Cacchi, S.,Marinelli, F.
, p. 6397 - 6400 (2007/10/02)
Aryl and alkylethynylsilanes are converted into 2,2-disubstituted vinylsilanes containing various common functional groups in the presence of aryl iodides, a palladium catalyst, formic acid, and a tertiary or secondary amine with high stereoselectivity an
