92552-36-8Relevant articles and documents
Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists
Xia, Jun,Song, Jianfei,Zhen, Le,Zhang, Xiuling,Lei, Xiantao,Zheng, Lina,Wang, Qiujuan,Sun, Hongbin
supporting information; experimental part, p. 3894 - 3897 (2011/08/06)
A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimet
A NOVEL SYNTHESIS OF 3,3-(SPIRO)SUBSTITUTED AZETIDINES
Froehlich, Johannes,Sauter, Fritz,Blasl, Karin
, p. 1879 - 1892 (2007/10/02)
A smooth and efficient new synthesis for 3,3-disubstituted azetidines, starting from readily available nitriles, was estabilished: α-hydroxymethylation of the starting materials, followed by O-tosylation and LiAlH4-reduction of the key intermediates thus obtained, led - via spontaneous cyclization of the intermediate amino derivatives - to 3,3-disubstituted azetidines.Scope and limitations of this new method were studied with respect to generalized applicability: the target compounds were accessible in good yields for a variety of starting materials (cyclic and acyclic di(hetero)aryl, (hetero)arylalkyl, dialkyl, as well as basic moieties).The products thus obtained may be of interest for ensuing conversions due to their unblocked nitrogen.
